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Promethazine is used for short-term treatment of difficulty sleeping in adults. This is because small amounts may pass into mothers milk. This medication may also be given to relax and sedate people before and after surgery, during labor, or to prevent and control the nausea and vomiting that may occur after surgery. Preventing Serious Tissue Injury with Intravenous Promethazine (Phenergan) This article has been cited by other articles in PMC. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Abnormal movements of the hands, legs, face, neck and tongue, eg tremor, twitching, rigidity (extrapyramidal effects).

Relieving the symptoms of allergic conditions such as hay fever (allergic rhinitis) and nettle rash (urticaria). However, sympathetic block and heparinization have been employed during acute management of promethazine extravasations. Short-term treatment of sleeping difficulties (insomnia) in adults. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount.

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Malpractice allegations spotlight anti-nausea medication. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start taking this medicine. It is possible, but not proven, that promethazine could lower the amount of milk a woman makes. Do not nurse a newborn while you are on Phenergan. If you order this item as Private, NO PBS stickers will be issued. Drinking alcohol could increase the side effects of this medication.

Recommended dosage

These cases led the FDA to add a second black box warning to its labeling in 2009. Other medicines, such as medicines for depression like MAOIs or tricyclics, antipsychotics and sleeping tablets may interact with promethazine causing unwanted effects. For anaphylaxis 25mg IV, repeated every 2 hours if necessary 25mg orally once. If you notice twitching, uncontrollable eye movements or uncontrollable movements of your lips, tongue, face, arms, or legs, call your doctor at once.

  • Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration. Promethazine is an antihistamine medication which can be used for short periods to help with sleeping difficulty. Label warnings This medication may cause drowsiness.
  • In some cases, surgical intervention, including fasciotomy, skin graft, or amputation, has been required.
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  • Phenylephrine and promethazine may also be used for purposes other than those listed in this medication guide. Your doctor or pharmacist can provide you with further information about these medications.
  • Short-term treatment of sleeping difficulties (insomnia) in adults. Preventing Serious Tissue Injury with Intravenous Promethazine (Phenergan) This article has been cited by other articles in PMC.

Side effects

If you have been prescribed injection, the nurse will give you the correct dose. Phenergan elixir contains maltitol (hydrogenated glucose syrup) and is not suitable for people with rare hereditary problems of fructose intolerance. Pregnancy and Promethazine There are no conclusive studies as to how promethazine impacts pregnant women. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference.

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This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Increased sensitivity of the skin to sunlight (photosensitivity). For more information view the Consumer Medical Information for this product (PDF document). Promethazine, owing to its pharmacological effects, has caused or may be suspected of causing, harmful effects on the human foetus or neonate without causing malformations. Producing sedation before surgery (preoperative sedation).

Phenergan facts:

  • If you are under 2 years of age, and if problems persist please consult doctor.
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  • Preferably, use lowest effective dosage in these patients and avoid concurrent use of other drugs with respiratory depressant effects.
  • Ask your doctor or pharmacist for details. These include being sick and confused following a viral illness.
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  • Please contact our pharmacist for more information.
  • Phenergan elixir contains maltitol (hydrogenated glucose syrup) and is not suitable for people with rare hereditary problems of fructose intolerance.
  • It provides symptomatic treatment for allergic conditions in the upper respiratory tract and skin.
  • If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking any medicine. Promethazine was developed in 1946 and approved for use by the Food and Drug Administration (FDA) on March 29, 1951.
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If you are having trouble producing milk, consider meeting with a lactation specialist. It does not take the place of talking to your doctor or pharmacist. Phenergan Sugar Free (orange flavour) Elixir should not be given to patients with allergies to sodium metabisulfite, sodium sulfite or sodium benzoate. Be sure to talk to your health care providers about all of your breastfeeding questions.


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Depending on your weight and tolerance, your doctor might change your dosage every now and then. Give the lowest dose that adequately relieves symptoms. Histamine is produced by the body in response to foreign substances that the body is allergic to. Phenergan should not be given to patients with a known hypersensitivity to promethazine or any of the excipients. This medicine should not be used if you are allergic to any of its ingredients.

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