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Buy Generic Pletal Online

Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Individuals with a history of kidney, liver issues as well as blood disorder, strokes and other cardiac problems should be cautious when taking the drug. Be sure to keep all doctor and laboratory appointments while taking cilostazol. One, or a combination of several of these effects may contribute to the clinical benefits and safety of this drug in IC and other disease conditions secondary to atherosclerosis. Consult your doctor before breast-feeding. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally.

Talk to your pharmacist for more details. There were no apparent trends toward a greater frequency of haemorrhagic adverse effects in patients taking cilostazol and ASA compared to patients taking placebo and equivalent doses of ASA. Pletal is an oral medication that should be taken according to the prescription of your doctor. Any specific instructions for a particular patient should be agreed with his health care adviser or doctor in charge of the case.

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All excipients comply with their respective European Pharmacopoeia monographs. No new or unexpected safety concerns arose during the review of information provided by the Marketing Authorisation Holder and it was, therefore, judged that the benefits of taking Cilostazol 50 and 100 mg Tablets outweigh the risks and Marketing Authorisations were granted. The drug is in a class of medicines known as platelet-aggregation inhibitors. Cilostazol should be discontinued promptly if there is clinical or laboratory evidence of haematological abnormalities.

Recommended dosage

But some medications can affect how Pletal works in your body, so your doctor needs to know what else you take. Sometimes they are serious, most of the time they are not. Pletal is for second-line use, in patients for whom lifestyle modifications (including stopping smoking and supervised exercise programs) and other appropriate interventions have failed to sufficiently improve their intermittent claudication symptoms. Taking Pletal with food has been shown to increase the maximum plasma concentrations (Cmax) of Pletal, which may be associated with an increased incidence of adverse effects. If you become pregnant while taking this medicine, tell your doctor immediately. Pletal can be used safely with many medications, such as those used to reduce the risk of heart attack and stroke. But make sure any site you do purchase these drugs form are approved stockists and can deliver to wherever it is in the world you live.

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  • Canada residents can call a provincial poison control center. Caution should be exercised when prescribing Pletal for patients with atrial or ventricular ectopy and patients with atrial fibrillation or flutter. This medicine may cause dizziness in some people.
  • Satisfactory Certificates of Analysis have been provided for these excipients.
  • Use this medication regularly to get the most benefit from it. Pletal 50mg Pletal Information Cilostazol is used to reduce the symptoms of intermittent claudication (pain in the legs that worsens when walking and improves when resting that is caused by narrowing of the blood vessels that supply blood to the legs).
  • It works by stopping blood cells called platelets from sticking together and prevents them from forming harmful clots. The vasodilatory effects of cilostazol may also be mediated through an increase in cAMP.

Side effects

Therefore if you have a child who appears to be in constant pain then you should seek medical attention and whilst that child may not be suffering from claudication, if he or she is the Doctor may go on to prescribe Pletal. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. There is not enough information to recommend the use of this medicine for children under the age of 18 years. Older adults may be more sensitive to the side effects of cilostazol. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally.

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Doses of 150 mg twice daily were investigated, however 100 mg twice daily provided the optimal risk to benefit ratio. The primary pre-specified analysis demonstrated a statistically significant longer walking distance in patients receiving cilostazol 100mg bid over placebo. It is usually taken twice a day, at least 30 minutes before or 2 hours after breakfast and dinner. Follow the directions on the prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Cilostazol can increase blood flow and the amount of oxygen that gets to the muscles. Sometimes they are serious, most of the time they are not.

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  • Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. The way in which both Pletal and Colostazol work once taken, is that they are able to decrease the action of an enzyme which can restrict the blood flow and these two drugs can also reduce the clotting ability of blood. The therapeutic indication that has been approved for cilostazol products in Europe is the improvement of the maximal and pain-free walking distances in patients with intermittent claudication (IC), who do not have rest pain and who do not have evidence of peripheral tissue necrosis (peripheral arterial disease Fontaine stage II).
  • Satisfactory certificates of analysis have been provided for all working standards. Properly discard this product when it is expired or no longer needed. Pletal should be taken 30 minutes before or two hours after breakfast and the evening meal.
  • Keep all medications away from children and pets. Taking Pletal Safely Before taking Pletal, be sure your doctor knows what other medications, herbs, and supplements you take. These included eight double-blind controlled phase III trials, two of which compared the efficacy of cilostazol with an active comparator (pentoxifylline) and placebo over 24 weeks.
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If you notice other effects not listed above, contact your doctor or pharmacist. Pletal solves this issue by increasing blood flow to the leg muscles by expanding the veins. Cilostazol is only recommended for patients whose symptoms have not improved sufficiently after making lifestyle changes (such as stopping smoking and increasing exercise) and after other appropriate interventions. Cilostazol may cause a condition that affects the heart rhythm (QT prolongation). Pharmacokinetic data from interaction studies has been reviewed and a dose reduction (to 50 mg twice a day) is now recommended when cilostazol is taken with strong inhibitors of these enzymes. This ensures that the correct amount of oxygen reaches the legs and as a result, muscle contractions can take place appropriately. Keep this leaflet with the medicine.


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Take this medication by mouth without food as directed by your doctor, usually twice daily, at least 30 minutes before or 2 hours after breakfast and dinner. This drug can be taken for both short and long periods of time, however always make sure you are regularly being monitored by your medical expert or your own Doctor or one familiar with your condition. Caution should be exercised when co-administering cilostazol with any other agents that inhibit platelet aggregation. An increase in cAMP results in an increase in the active form of protein kinase A (PKA), which is directly related with an inhibition in platelet aggregation. Your doctor will probably tell you not to take cilostazol.

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