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Buy Generic Prometrium Online

There is suggestive evidence of a small increased risk of breast cancer with oestrogen replacement therapy. Progesterone belongs to the class of medications called progestins. An increased risk of endometrial cancer has been reported with the use of unopposed estrogen therapy in a woman with a uterus. If you experience difficulty in swallowing PROMETRIUM Capsules, it is recommended that you take your daily dose at bedtime with a glass of water while in the standing position. When a woman becomes pregnant, her corpus luteum (empty egg follicle) makes progesterone during early pregnancy. PROMETRIUM® is intended for use in women with an intact uterus as an adjunct to estrogen replacement therapy. For these women, bedtime dosing is advised. Most studies show no significant increased risk associated with the use of estrogens for less than 1 year. Women should be encouraged to participate in the national breast cancer screening programme (mammography) and the national cervical cancer screening programme (cervical cytology) as appropriate for their age.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. It is important that the modest increased risk of being diagnosed with breast cancer after 4 years of treatment with combined estrogen plus progestin HRT (as reported in the results of the WHI trial) be discussed with the patient and weighed against its known benefits. In dogs, long-term intramuscular injections produced nodular hyperplasia and benign and malignant mammary tumors.

How to buy Prometrium

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Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. The pathologist should be advised of progestin therapy when relevant specimens are submitted. Prometrium is a brand name for hormones known as progestins. Prometrium capsules 200mg reduce the risk of endometrial cancer which can be caused by oestrogen only HRT, without interfering with the beneficial effects of oestrogen, such as preventing bone loss and regulating cholesterol.

Recommended dosage

Breasts and pelvic organs should be appropriately examined and a Papanicolaou smear should be performed. Thereafter, examinations should be made at intervals at least once a year. Consistent with the WHI clinical trials, observational studies have also reported an increased risk of breast cancer for estrogen plus progestin therapy, and a smaller increased risk for estrogen-alone therapy, after several years of use. Although doses greater than 300 mg per day were not studied in females, serum concentrations from a study in male volunteers appeared linear and dose proportional between 100 mg per day and 400 mg per day. Increased risk of liver cancer with OCP use; risk increases with longer duration of OCP use.

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  • Use with caution in patients with history of depression. Ask your doctor or pharmacist if you have any questions. Evidence suggests long-term use of OCPs, 5 or more years, may be associated with increased risk.
  • Some studies link OCP use with increased risk of breast cancer, whereas other studies have not shown a change in risk. Nausea, bloating, breast tenderness, headache, change in vaginal discharge, mood swings, blurred vision, dizziness, or drowsiness may occur.
  • Endometrial biopsy should be done when indicated.
  • This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, if conception occurs; if not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Progesterone is synthesized from a starting material from a plant source and is chemically identical to progesterone of human ovarian origin.

Side effects

It is not known whether concurrent progesterone influences the risk of cancer in post-menopausal women taking hormone replacement therapy. Follow your doctor's dosing instructions very carefully. Evidence suggests long-term use of OCPs, 5 or more years, may be associated with increased risk. A doctor may prescribe Prometrium vaginally as a way to increase a woman's natural progesterone in the hopes of maintaining pregnancy. Prior to taking hormone replacement therapy (and at regular intervals thereafter) each woman should be assessed. A small percentage of women may experience extreme dizziness and/or drowsiness during initial therapy. Progesterone exerts significant anti-proliferative effects on the estrogenized endometrium and maintains sufficient control of endometrial mitotic activity through suppression of nuclear estradiol receptors, significant reduction in epithelial and stromal DNA synthesis and induction of 17B-estradiol dehydrogenase and isocitric dehydrogenase activity.

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Most women are able to stop the supplement around 12 weeks. Prometrium capsules 200mg reduce the risk of endometrial cancer which can be caused by oestrogen only HRT, without interfering with the beneficial effects of oestrogen, such as preventing bone loss and regulating cholesterol. If you are about to have major surgery and are taking progesterone, be sure to tell your doctor because you may need to stop taking progesterone about four weeks prior to your surgery. Most women are able to stop the supplement around 12 weeks.

Prometrium facts:

  • The pathologist should be advised of progestin therapy when relevant specimens are submitted. It promotes the development of the mammary glands, causes changes in the endometrium, which lines the uterus, relaxes uterine smooth muscles, blocks ovulation within the ovaries, and maintains pregnancy.
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  • This means progesterone therapy is often a short-term option for reducing her miscarriage risk. Many women who have a history of miscarriages or undergo fertility treatment will receive a prescription for Prometrium for the first 12 days of their cycle or for the first three months of pregnancy.
  • Progesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy. Women who are older than 65 and have finished menopause should avoid progesterone because it puts you at increased risk for dementia.
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  • The overall benefits and possible risks of hormone replacement therapy should be fully considered and discussed with patients. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.
  • Breast awareness should also be encouraged and women advised to report any changes in their breasts to their doctor or nurse.
  • Concomitant food ingestion increases the bioavailability of Prometrium. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
  • Women who take high doses of estrogen should receive a progesterone dose of 300 mg per day. You may need to stop the medication for a time or take special precautions because of the increased risk for blood clots.
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The mineralocorticoid effect of progesterone metabolites is itself largely antagonized by the antimineralocorticoid effect of progesterone. Breasts and pelvic organs should be appropriately examined and a Papanicolaou smear should be performed. May cause dizziness; use caution when driving a motor vehicle or operating machinery. Use with caution in patients with diseases that could become exacerbated by fluid retention including epilepsy, migraine, renal dysfunction, diabetes, or asthma. If you are about to have major surgery and are taking progesterone, be sure to tell your doctor because you may need to stop taking progesterone about four weeks prior to your surgery.

Precautions

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Most studies show no significant increased risk associated with the use of estrogens for less than 1 year. Read all patient information, medication guides, and instruction sheets provided to you. Notify your doctor beforehand if you will be having surgery or will be confined to a chair/bed for a long time (e.g., a long plane flight). You may find yourself experiencing some additional nausea and dizziness beyond your early pregnancy symptoms. It can be harmful for people to take this medication if their doctor has not prescribed it. Clinical surveillance of all women using estrogen plus progestin therapy is important.

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