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Buy Generic Zetia Online

Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. The mean area under the curve of total ezetimibe was reduced by approximately 55% when given concurrently with cholestyramine. To help avoid interactions, your doctor should manage all of your medications carefully. Plasma concentrations for total Ezetimibe are about 2-folds higher in the elderly (65 years old) than in the young (18-45 years old). Low-density lipoprotein (LDL), the major cholesterol carrier in human blood, is the offending agent of coronary heart disease (CHD), which remains the leading cause of death in developed countries. Tell your doctor if you are pregnant or plan to become pregnant. Cyclosporine concentrations should be monitored in patients receiving ZETIA and cyclosporine. Do not adjust the dosages on your own and make sure that you take it regularly. Ezetimibe works by reducing the amount of cholesterol your body absorbs from your diet.

Clinical studies have demonstrated that elevated levels of total cholesterol (total-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein B (Apo B), the major protein constituent of LDL, promote human atherosclerosis. Take Generic Zetia as recommended by the doctor. Do not take too much of this drug and do not discontinue the use of it before you talk to your doctor. One clinical study showed that adding Zetia to statin medicine reduced LDL levels by an average of an additional 25 percent.

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Do not take too much of this drug and do not discontinue the use of it before you talk to your doctor. In post-marketing reports, ezetimibe has been rarely associated with myalgia, hepatitis, acute pancreatitis, thrombocytopenia, and rhabdomyolysis. However, myopathy and rhabdomyolysis are known adverse reactions to HMG-CoA reductase inhibitors and other lipid-lowering drugs. Generic ezetimibe is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Ezetimibe is classified as Pregnancy Category C, and its combined use with Statins is contraindicated in pregnant and nursing women. Zetia may increase LDL-cholesterol uptake into cells and decrease levels of LDL in blood plasma.

Recommended dosage

The liver can synthesize cholesterol, take up cholesterol from the blood from circulating lipoproteins, or take up cholesterol absorbed by the small intestine. In post-marketing reports, ezetimibe has been rarely associated with myalgia, hepatitis, acute pancreatitis, thrombocytopenia, and rhabdomyolysis. Ezetimibe has a different mechanism of action and lowers blood cholesterol by reducing the absorption of cholesterol from the intestine. Take Generic Zetia as recommended by the doctor.

  • This is not a complete list of possible side effects. Both ezetimibe and its glucuronide are active in blocking cholesterol absorption.
  • Trials found that Zetia, in combination with statins, may not be as effective as Zetia by itself.
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  • Generic name for this drug is ezetimibe and it can be used alone or in combination with simvastatin, another drug used for hypercholesterolemia. Caution should be exercised when using ZETIA and cyclosporine concomitantly due to increased exposure to both ezetimibe and cyclosporine. Tell your doctor if you are breast-feeding a baby.
  • It is available in generic and brand versions. Combination Therapy with Fenofibrate ZETIA, administered in combination with fenofibrate, is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia.

Side effects

Cyclosporine concentrations should be monitored in patients receiving ZETIA and cyclosporine. Ezetimibe is neither an inhibitor nor an inducer of cytochrome P450 isoenzymes, so metabolism of other agents is not affected. The most commonly used class of drugs for lowering cholesterol levels, the statins, act by preventing the production of cholesterol by the liver. Epidemiologic studies have established that cardiovascular morbidity and mortality vary directly with the level of total-C and LDL-C and inversely with the level of HDL-C. The drug is now threatened by its first generic version, produced by Par Pharmaceutical (Par), an operating company of Dublin's Endo International (Endo).

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You should not use Zetia if you have moderate to severe liver disease. Clinical studies of ZETIA (administered alone or with an HMG-CoA reductase inhibitor) demonstrated that ZETIA was generally well tolerated. That concept supports the rationale that in patients with small LDL particles combination therapy with statins, statins/ezetimibe and drugs that shift LDL size such as fibrates or niacin makes great sense. Unlike other cholesterol-reducing agents, ezetimibe localizes and appears to act at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. In post-marketing experience with ZETIA, cases of myopathy and rhabdomyolysis have been reported regardless of causality.

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  • Therefore, no dosage adjustment is necessary in the elderly. It is also found effective in the treatment of high blood sitosterol and campesterol along with diet therapy.
  • Although this may be concerning news for Merck, for Endo the Zetia generics will provide an opportunity for the company to boost its revenue following recent economic troubles.
  • It works by reducing the amount of cholesterol absorbed by the small intestine. In post-marketing reports, ezetimibe has been rarely associated with myalgia, hepatitis, acute pancreatitis, thrombocytopenia, and rhabdomyolysis.
  • An interaction is when a substance changes the way a drug works.
  • Ezetimibe and ezetimibe­glucuronide are the major drug-derived compounds detected in plasma, constituting approximately 10 to 20% and 80 to 90% of the total drug in plasma, respectively. Ezetimibe in conjunction with a Statins is contraindicated in patients with liver disease or unexplained serum transaminase elevation.
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Concomitant administration of Ezetimibe with Cholestyramine decreases the mean AUC of Ezetimibe by approximately 55%. Metabolism and Excretion Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation (a phase II reaction) with subsequent biliary and renal excretion. This leads to a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood. It is available in generic and brand versions.

Precautions

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However, myopathy and rhabdomyolysis are known adverse reactions to HMG-CoA reductase inhibitors and other lipid-lowering drugs. Hepatic production of triglycerides (TG) is what creates small LDL and HDL. Lipid-altering agents should be used in addition to an appropriate diet (including restriction of saturated fat and cholesterol) and when the response to diet and other non-pharmacological measures has been inadequate. ZETIA reduces total-C, LDL-C, Apo B, and TG, and increases HDL-C in patients with hypercholesterolemia. Additionally, there is no apparent benefit to therapy during pregnancy, and safety in pregnant women has not been established. Generic ezetimibe is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The effects of ezetimibe given either alone or in addition to an HMG-CoA reductase inhibitor or fenofibrate on cardiovascular morbidity and mortality have not been established.

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